Effects of Curcumin-Loaded Poly(Lactic-Co-Glycolic Acid) Nanoparticles in MDA-MB231 Human Breast Cancer Cells
Ankur Sharma, Susan Hawthorne, Saurabh Kumar Jha, Niraj Kumar Jha, Dhruv Kumar, Girgis Samuel, Vineet Kumar Goswami, Gaurav Gupta, Sachin Kumar Singh, Harish Dureja, Dinesh Kumar Chellappan, Kamal Dua
Abstract
Aim: This study was aimed at evaluating the anticancer potential of curcumin-loaded poly(lactic-co-glycolic acid) (PLGA) based nanoparticles (NPs) in MDA-MB231 human breast cancer cells. Methods: Curcumin-loaded PLGA NPs were developed using a modified solvent evaporation technique. Physical characterization was performed on the formulated NPs. Furthermore, in vitro experiments were conducted to study the biological activity of the curcumin-loaded NPs. Results: Curcumin-loaded PLGA NPs demonstrated high encapsulation efficiency and sustained payload release. Moreover, the NPs exhibited a significant reduction in cell viability, cell migration and cell invasion in the MDA-MB231 cells. Conclusion: The study revealed that the formulated curcumin-loaded PLGA NPs possessed significant anti-metastatic properties. The findings showcased the possible potential of curcumin-loaded NPs in the management of debilitating conditions such as cancer. In addition, this study could form the basis for further research and advancements in this area.