A domino reaction from a sensitive azide: the impact of positional isomerism on chemical reactivity featuring <i>ortho</i> azido/nitro substituted derivatives
Vikranth Thaltiri, Jatinder Singh, Richard J. Staples, Jean’ne M. Shreeve
Abstract
This study highlights for the first time the impact of positional isomerism on chemical reactivity which involves a domino reaction, salt formation, cyclization, and nucleophilic substitution.
Topics & Concepts
Reactivity (psychology)DominoNitroAzideChemistryCascade reactionMedicinal chemistryCombinatorial chemistryOrganic chemistryMedicineCatalysisAlkylPathologyAlternative medicineChemical Reactions and MechanismsEnergetic Materials and CombustionChemical Reaction Mechanisms