Enzymatic activation of pyruvate kinase increases cytosolic oxaloacetate to inhibit the Warburg effect
Elizabeth K. Wiese, Sadae Hitosugi, Sharon T. Loa, Annapoorna Sreedhar, Lindsey G. Andres‐Beck, Kiran Kurmi, Yuan‐Ping Pang, Larry M. Karnitz, Wilson I. Gonsalves, Taro Hitosugi
Topics & Concepts
PKM2Warburg effectLactate dehydrogenase AGlycolysisPyruvate kinaseLactate dehydrogenaseActivator (genetics)Cancer cellBiochemistryCitrate synthaseAnaerobic glycolysisBiologyChemistryEnzymeCancer researchCancerReceptorGeneticsCancer, Hypoxia, and MetabolismMitochondrial Function and PathologyATP Synthase and ATPases Research