Host Cathelicidin Exacerbates Group B<i>Streptococcus</i>Urinary Tract Infection
Kathryn A. Patras, Alison Coady, P. Gireesh Babu, Samuel R. Shing, Albert Ha, Emma Rooholfada, Stephanie L. Brandt, Matthew Geriak, Richard L. Gallo, Victor Nizet
Abstract
Certain populations such as diabetic individuals are at increased risk for developing urinary tract infections (UTI), although the underlying reasons for this susceptibility are not fully known. Additionally, diabetics are more likely to become infected with certain types of bacteria, such as group B Streptococcus (GBS). In this study, we find that an antimicrobial peptide called cathelicidin, which is thought to protect the bladder from infection, is ineffective in controlling GBS and alters the type of immune cells that migrate to the bladder during infection. Using a mouse model of diabetes, we observe that diabetic mice are more susceptible to GBS infection even though they also have more infiltrating immune cells and increased production of cathelicidin. Taken together, our findings identify this antimicrobial peptide as a potential contributor to increased susceptibility of diabetic individuals to GBS UTI.