Human defensin-inspired discovery of peptidomimetic antibiotics
Gan Luo, Jue Zhang, Hanbin Wang, Yaqi Sun, Baoli Cheng, Zhipeng Xu, Yan Zhang, Hui Li, Wuyuan Lu, Elizabeta Nemeth, Tomas Ganz, Xiangming Fang
Abstract
SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.
Topics & Concepts
PeptidomimeticDefensinAntibioticsDrug discoveryComputer scienceComputational biologyMedicineBiologyBioinformaticsMicrobiologyPeptideAntimicrobialBiochemistryAntimicrobial Peptides and ActivitiesBiochemical and Structural CharacterizationChemical Synthesis and Analysis