In vitro siRNA-mediated GPX4 and AKT1 silencing in oxaliplatin resistance cancer cells induces ferroptosis and apoptosis
Morteza Golbashirzadeh, Hamid Reza Heidari, Ali Asghar Aghamolayi, Yasin Fattahi, Mehdi Talebi, Ahmad Yari Khosroushahi
Topics & Concepts
OxaliplatinDownregulation and upregulationApoptosisCancer researchGene silencingGPX4Programmed cell deathViability assayCell cultureBiologyCancer cellCancerColorectal cancerOxidative stressGeneBiochemistrySuperoxide dismutaseGeneticsGlutathione peroxidaseRNA modifications and cancerCancer-related gene regulationFerroptosis and cancer prognosis