Design, synthesis, and biological evaluation of 1-styrenyl isoquinoline derivatives for anti-hepatocellular carcinoma activity and effect on mitochondria
Yuqing Wang, Lin Long, Linsheng Zhuo, Honghua Zhang, Tian Luo, Jiedan Deng, Yuying Wang, Li Zhao, Zhen Wang, Peng Xue, Zhen Wang, Peng Xue
Topics & Concepts
ApoptosisIsoquinolineChemistryPI3K/AKT/mTOR pathwayProtein kinase BCell growthCell cycleHepatocellular carcinomaMitochondrionCancer researchResveratrolCellCell biologyPharmacologyBiochemistryStereochemistryBiologyCancer Mechanisms and TherapySirtuins and Resveratrol in MedicineUbiquitin and proteasome pathways