Towards a “Testis in a Dish”: Generation of Mouse Testicular Organoids that Recapitulate Testis Structure and Expression Profiles
Aviya Stopel, Cheli Lev, Stav Dahari, Or Adibi, Leah Armon, Nitzan Gonen
Abstract
. These testis organoids are a promising model system for basic research of testes development and function, with translational applications for elucidation and treatment of developmental sex disorders and infertility.
Topics & Concepts
OrganoidBiologySertoli cellCell biologySpermatogenesisEmbryonic stem cellIn vivoIn vitroEndocrinologyGeneGeneticsSperm and Testicular FunctionSexual Differentiation and DisordersGenetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities