Endotoxins: Pyrogens, LAL Testing and Depyrogenation

Abstract

Historical foundations of pyrogen research pyrogen, endotoxin, and fever - an overview endotoxin structure, function, activity the host response to endotoxin non-endotoxin microbial pyrogens (lesser endotoxins and superantigens) non-microbial exogenous pyrogens and drug fever pharmaceutical manufacturing contamination control endotoxin as a standard the rabbit pyrogen test LAL discovery, mechanism, and application LAL assay development, validation and regulation.

Topics & Concepts