The Impact of Prior Infection and Age on Antibody Persistence After Severe Acute Respiratory Syndrome Coronavirus 2 Messenger RNA Vaccine
Elizabeth Fraley, Cas LeMaster, Santosh Khanal, Dithi Banerjee, Tomi Pastinen, Elin Grundberg, Rangaraj Selvarangan, Todd Bradley
Abstract
Determining the duration of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines is critical for informing the timing of booster immunization. Many genetic and environmental factors could influence both the magnitude and persistence of the antibody response. Here, we showed that SARS-CoV-2 infection before vaccination and age affected the decay of antibody responses to the SARS-CoV-2 messenger RNA vaccine.
Topics & Concepts
MedicineImmunologyVaccinationPersistence (discontinuity)AntibodyCoronavirusVirologyImmunityRespiratory systemImmunizationImmune systemCoronavirus disease 2019 (COVID-19)DiseaseInfectious disease (medical specialty)Internal medicineEngineeringGeotechnical engineeringSARS-CoV-2 and COVID-19 ResearchAnimal Virus Infections StudiesViral gastroenteritis research and epidemiology