Mechanistic Modeling of Mycobacterium tuberculosis Infection in Murine Models for Drug and Vaccine Efficacy Studies
Nan Zhang, Natasha Strydom, Sandeep Tyagi, Heena Soni, Rokeya Tasneen, Eric L. Nuermberger, Rada Savic
Abstract
Tuberculosis (TB) drug, regimen, and vaccine development rely heavily on preclinical animal experiments, and quantification of bacterial and immune response dynamics is essential for understanding drug and vaccine efficacy. A mechanism-based model was built to describe Mycobacterium tuberculosis H37Rv infection over time in BALB/c and athymic nude mice, which consisted of bacterial replication, bacterial death, and adaptive immune effects.
Topics & Concepts
Mycobacterium tuberculosisTuberculosisDrugMicrobiologyVirologyVaccine efficacyMedicineTuberculosis vaccinesImmunologyBiologyPharmacologyVaccinationPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisDiagnosis and treatment of tuberculosis