Extension of the Mechanistic Tissue Distribution Model of Rodgers and Rowland by Systematic Incorporation of Lysosomal Trapping: Impact on Unbound Partition Coefficient and Volume of Distribution Predictions in the Rat
Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker, Philip Lienau
Topics & Concepts
Physiologically based pharmacokinetic modellingLysosomeChemistryLipophilicityVolume of distributionPharmacokineticsPhospholipidosisDistribution (mathematics)Partition coefficientDistribution VolumeBiochemistryBiophysicsPharmacologyChromatographyBiologyEnzymePhospholipidMembraneMathematicsMathematical analysisAdvanced Fluorescence Microscopy TechniquesCalcium signaling and nucleotide metabolismSphingolipid Metabolism and Signaling