Phototriggered labeling and crosslinking by 2-nitrobenzyl alcohol derivatives with amine selectivity
Chenxi Wang, Yuan Liu, Chunyan Bao, Yuan Xue, Yaowu Zhou, Dasheng Zhang, Qiuning Lin, Linyong Zhu
Abstract
Here we report the use of 2-nitrobenzyl alcohol (NB) as a photoreactive group with amine selectivity and explore its applications for photoaffinity labeling and crosslinking of biomolecules. This work confirms that NB is an efficient photoreactive group and has great potential in drug discovery, chemical biology and protein engineering.
Topics & Concepts
SelectivityAmine gas treatingChemistryAlcoholCombinatorial chemistryOrganic chemistryCatalysisPhotochromic and Fluorescence ChemistryClick Chemistry and ApplicationsChemical Synthesis and Analysis