Ctdnep1 and Eps8L2 regulate dorsal actin cables for nuclear positioning during cell migration
Francisco J. Calero-Cuenca, Daniel S. Osório, Sofia Carvalho-Marques, Sree Rama Chaitanya Sridhara, Luis M. Oliveira, Yue Jiao, Jheimmy Diaz, Cátia S. Janota, Bruno Cadot, Edgar R. Gomes
Abstract
on nuclear positioning and cell migration. We demonstrate that Ctdnep1 and Eps8L2 directly interact, and this interaction is important for nuclear positioning and cell migration. We also show that Ctdnep1 and Eps8L2 are involved in the formation and thickness of dorsal actin cables required for TAN lines engagement during nuclear movement. We propose that Ctdnep1-Eps8L2 interaction regulates dorsal actin cables for nuclear movement during cell migration.
Topics & Concepts
BiologyDorsumCell biologyActinCell migrationCellAnatomyGeneticsCellular Mechanics and InteractionsNuclear Structure and FunctionMicrotubule and mitosis dynamics