Beyond blood biomarkers: the role of SelectMDX in clinically significant prostate cancer identification
Matteo Ferro, Bernardo Rocco, Martina Maggi, Giuseppe Lucarelli, Ugo Giovanni Falagario, Francesco Del Giudice, Felice Crocetto, Biagio Barone, Evelina La Civita, Francesco Lasorsa, A. Brescia, Michele Catellani, Gian Maria Busetto, Octavian Sabin Tătaru, Daniela Terracciano
Abstract
INTRODUCTION: New potential biomarkers to pre-intervention identification of a clinically significant prostate cancer (csPCa) will prevent overdiagnosis and overtreatment and limit quality of life impairment of PCa patients. AREAS COVERED: We have developed a comprehensive review focusing our research on the increasing knowledge of the role of SelectMDX® in csPCa detection. Areas identified as clinically relevant are the ability of SelectMDX® to predict csPCa in active surveillance setting, its predictive ability when combined with multiparametric MRI and the role of SelectMDX® in the landscape of urinary biomarkers. EXPERT OPINION: Several PCa biomarkers have been developed either alone or in combination with clinical variables to improve csPCa detection. SelectMDX® score includes genomic markers, age, PSA, prostate volume, and digital rectal examination. Several studies have shown consistency in the ability to improve detection of csPCa, avoidance of unnecessary prostate biopsies, helpful in decision-making for clinical benefit of PCa patients with future well designed, and impactful studies.