Fluorofenidone ameliorates cholestasis and fibrosis by inhibiting hepatic Erk/-Egr-1 signaling and Tgfβ1/Smad pathway in mice
Huiwen Wang, Jian Zhang, Xiaoxun Zhang, Nan Zhao, Zongtao Zhou, Lijian Tao, Lei Fu, Shifang Peng, Jin Chai
Topics & Concepts
CholestasisInternal medicineFibrosisEndocrinologySMADUrsodeoxycholic acidObeticholic acidBile acidHepatic fibrosisInflammationMedicineAlkaline phosphataseChemistryTransforming growth factorBiochemistryEnzymeReceptorAgonistDrug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and TreatmentsLiver Disease Diagnosis and Treatment