Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition
Minh V. Huynh, Derek Parsonage, Tom E. Forshaw, Venkat R. Chirasani, G. Aaron Hobbs, Hanzhi Wu, Jingyun Lee, Cristina M. Furdui, Leslie B. Poole, Sharon L. Campbell
Abstract
drug discovery efforts, and identify the occurrence of G12C oxidation with currently unknown biological ramifications.
Topics & Concepts
RedoxKRASChemistryCovalent bondBiophysicsBiochemistryCell biologyBiologyMutationGeneOrganic chemistryEnzyme Structure and FunctionProtein Structure and DynamicsProtein Kinase Regulation and GTPase Signaling