Intrinsic ADRB2 inhibition improves CAR-T cell therapy efficacy against prostate cancer
Iqra Ajmal, Muhammad Asad Farooq, Yixin Duan, Jie Yao, Yaoxin Gao, Xinhui Hui, Yujia Ge, Yiran Chen, Yaojun Ren, Bingtan Du, Wenzheng Jiang
Abstract
-CAR-T cells performed better than conventional CAR-T cells in eradicating prostate tumors. The study provides the basis for future clinical and translational CAR-T cell research to focus on adrenergic stress-mediated challenges in the tumor microenvironment of stressed tumors.
Topics & Concepts
Chimeric antigen receptorIn vivoProstate cancerCancer researchReceptorT cellIn vitroImmunotherapyCancerMedicineChemistryPharmacologyImmunologyBiologyImmune systemInternal medicineBiochemistryBiotechnologyCAR-T cell therapy researchImmune Cell Function and InteractionCancer Immunotherapy and Biomarkers