The Central Role of Osteocytes in the Four Adaptive Pathways of Bone’s Mechanostat
Julie M. Hughes, Colleen M. Castellani, Kristin L. Popp, Katelyn I. Guerriere, Ronald W. Matheny, Bradley C. Nindl, Mary Bouxsein
Abstract
We review evidence supporting an updated mechanostat model in bone that highlights the central role of osteocytes within bone's four mechanoadaptive pathways: 1) formation modeling and 2) targeted remodeling, which occur with heightened mechanical loading, 3) resorption modeling, and 4) disuse-mediated remodeling, which occur with disuse. These four pathways regulate whole-bone stiffness in response to changing mechanical demands.
Topics & Concepts
Bone remodelingBone resorptionBone remodeling periodBone formationNeuroscienceMechanotransductionCell biologyChemistryBiologyMedicineOsteoclastEndocrinologyInternal medicineReceptorBone health and osteoporosis researchBone Metabolism and DiseasesCellular Mechanics and Interactions