Development of curcumin-loaded zein nanoparticles for transport across the blood–brain barrier and inhibition of glioblastoma cell growth
Huaiying Zhang, Winant L. van Os, Xiaobo Tian, Guangyue Zu, Laís Ribovski, Reinier Bron, Jeroen Bussmann, Alexander Kros, Yong Liu, Inge S. Zuhorn
Abstract
Zein-polydopamine nanoparticles functionalized with G23 peptide cross an in vitro blood–brain barrier and penetrate tumor spheroids. When loaded with curcumin they effectively reduce proliferation, migration, and viability of C6 glioma cells.
Topics & Concepts
CurcuminGliomaChemistrySpheroidIn vivoBlood–brain barrierFlow cytometryDrug deliveryCancer researchApoptosisBiophysicsCell biologyIn vitroBiochemistryMolecular biologyBiologyCentral nervous systemNeuroscienceOrganic chemistryBiotechnologyNanoparticle-Based Drug DeliveryRNA Interference and Gene DeliveryDendrimers and Hyperbranched Polymers