Novel anilide and benzylamide derivatives of arylpiperazinylalkanoic acids as 5-HT1A/5-HT7 receptor antagonists and phosphodiesterase 4/7 inhibitors with procognitive and antidepressant activity
Agnieszka Jankowska, Grzegorz Satała, Marcin Kołaczkowski, Adam Bucki, Monika Głuch‐Lutwin, Artur Świerczek, Krzysztof Pociecha, Anna Partyka, Magdalena Jastrzębska‐Więsek, Annamaria Lubelska, Gniewomir Latacz, Alicja Gawalska, Andrzej J. Bojarski, Elżbieta Wyska, Grażyna Chłoń‐Rzepa
Topics & Concepts
ChemistryPharmacologyBehavioural despair testReceptor antagonistAntidepressantImipramineIC50AntagonistPhosphodiesteraseReceptorIn vitro5-HT1A receptor5-HT receptorSerotoninBiochemistryEnzymeHippocampusInternal medicineMedicineAlternative medicinePathologyPhosphodiesterase function and regulationReceptor Mechanisms and SignalingPhenothiazines and Benzothiazines Synthesis and Activities