Restoring expression of Stathmin-2: a novel strategy to treat TDP-43 proteinopathies
Sonja Menge, Lorena Decker, Axel Freischmidt
Abstract
In a recent study published in Science , Baughn et al. revealed that TDP-43 acts as a steric block in STMN2 pre-mRNA processing preventing inclusion of a deleterious cryptic exon, and present strategies for substituting this function to compensate for the loss of nuclear TDP-43 in a variety of neurodegenerative diseases (NDs) including amyotrophic lateral sclerosis (ALS). 1
Topics & Concepts
StathminCancer researchComputational biologyMedicineBioinformaticsBiologyCell biologyPhosphorylationAmyotrophic Lateral Sclerosis ResearchGenetic Neurodegenerative DiseasesNeurogenetic and Muscular Disorders Research