Recent Strategies in Nickel-Catalyzed C–H Bond Functionalization for Nitrogen-Containing Heterocycles
Ke Yang, Zhi Li, Qingyue Hu, Mazen Elsaid, Chong Liu, Jun Chen, Haibo Ge
Abstract
N-heterocycles are ubiquitous in natural products, pharmaceuticals, organic materials, and numerous functional molecules. Among the current synthetic approaches, transition metal-catalyzed C–H functionalization has gained considerable attention in recent years due to its advantages of simplicity, high atomic economy, and the ready availability of starting materials. In the field of N-heterocycle synthesis via C–H functionalization, nickel has been recognized as one of the most important catalysts. In this review, we will introduce nickel-catalyzed intramolecular and intermolecular pathways for N-heterocycle synthesis from 2008 to 2021.
Topics & Concepts
Surface modificationIntramolecular forceCatalysisNickelIntermolecular forceCombinatorial chemistryChemistryMoleculeNanotechnologyMaterials scienceOrganic chemistryPhysical chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCyclopropane Reaction Mechanisms