A PAS Protein Directs Metabolic Reprogramming during Cryptococcal Adaptation to Hypoxia
Youbao Zhao, Xiaorong Lin
Abstract
C. neoformans is the main causative agent of fungal meningitis that is responsible for about 15% of all HIV-related deaths. Although an obligate aerobic fungus, C. neoformans is well adapted to hypoxia conditions that the fungus could encounter in the host or the environment.
Topics & Concepts
Cryptococcus neoformansCryptococcal meningitisFungusMicrobiologyHypoxia (environmental)ObligateBiologyAdaptation (eye)ReprogrammingCryptococcosisFilamentous fungusImmunologyHuman immunodeficiency virus (HIV)ChemistryGeneGeneticsEcologyOxygenNeuroscienceViral diseaseOrganic chemistryBotanyFungal Infections and StudiesCytomegalovirus and herpesvirus researchToxoplasma gondii Research Studies