Genomic Sequencing Surveillance to Identify Respiratory Syncytial Virus Mutations, Arizona, USA
LaRinda A. Holland, Steven C. Holland, Matthew F. Smith, Victoria R. Leonard, Vel Murugan, Lora Nordstrom, Mary Mulrow, Raquel Salgado, Michael White, Efrem S. Lim
Abstract
We conducted surveillance of respiratory syncytial virus (RSV) genomic sequences for 100 RSV-A and 27 RSV-B specimens collected during November 2022-April 2023 in Arizona, USA. We identified mutations within prefusion F-protein antigenic sites in both subtypes. Continued genomic surveillance will be critical to ensure RSV vaccine effectiveness.
Topics & Concepts
VirologyVirusBiologyGenomic sequencingGenomeGeneticsGeneRespiratory viral infections researchNeonatal Respiratory Health ResearchCongenital Diaphragmatic Hernia Studies