Animal Model To Study Klebsiella pneumoniae Gastrointestinal Colonization and Host-to-Host Transmission
Taylor M. Young, Andrew S. Bray, Ravinder Nagpal, David L. Caudell, Hariom Yadav, M. Ammar Zafar
Abstract
An important yet poorly understood facet of the life cycle of a successful pathogen is host-to-host transmission. Hospital-acquired infections (HAI) resulting from the transmission of drug-resistant pathogens affect hundreds of millions of patients worldwide. Klebsiella pneumoniae , a Gram-negative bacterium, is notorious for causing HAI, with many of these infections difficult to treat, as K. pneumoniae has become multidrug resistant. Epidemiological studies suggest that K. pneumoniae host-to-host transmission requires close contact and generally occurs through the fecal-oral route.
Topics & Concepts
BiologyHost (biology)ColonizationKlebsiella pneumoniaeMicrobiologyTransmission (telecommunications)Host factorsVirologyEscherichia coliEcologyVirusEngineeringGeneBiochemistryElectrical engineeringAntibiotic Resistance in BacteriaClostridium difficile and Clostridium perfringens researchEscherichia coli research studies