The COVID-19 Drug and Gene Set Library
Maxim V. Kuleshov, Daniel Stein, Daniel Clarke, Eryk Kropiwnicki, Kathleen M. Jagodnik, Alon Bartal, John Erol Evangelista, Jason Hom, Minxuan Cheng, Allison Bailey, Abigail Zhou, Laura B. Ferguson, Alexander Lachmann, Avi Ma’ayan
Abstract
drug screens for COVID-19 repurposing candidates. Surprisingly, we observe low overlap across screens while highlighting overlapping candidates that should receive more attention as potential therapeutics for COVID-19. Overall, the COVID-19 Drug and Gene Set Library can be used to identify community consensus, make researchers and clinicians aware of new potential therapies, enable machine-learning applications, and facilitate the research community to work together toward a cure.
Topics & Concepts
Drug repositioningRepurposingCoronavirus disease 2019 (COVID-19)DrugSet (abstract data type)Drug discoveryComputer scienceSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Computational biologyDownloadMedicineWorld Wide WebBioinformaticsBiologyPharmacologyInfectious disease (medical specialty)Programming languagePathologyEcologyDiseaseSARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery MethodsCRISPR and Genetic Engineering