Different forms of vitamin E and metabolite 13’-carboxychromanols inhibit cyclooxygenase-1 and its catalyzed thromboxane in platelets, and tocotrienols and 13’-carboxychromanols are competitive inhibitors of 5-lipoxygenase
Na-Young Park, Suji Im, Qing Jiang
Topics & Concepts
CyclooxygenaseArachidonate 5-lipoxygenaseChemistryLipoxygenaseVitamin EPlateletBiochemistryThromboxaneMetabolitePharmacologyEnzymeThromboxane B2Arachidonic acidAntioxidantInternal medicineBiologyMedicineAntioxidant Activity and Oxidative StressEstrogen and related hormone effectsInflammatory mediators and NSAID effects