Novel crystal forms of Entresto: a supramolecular complex of trisodium sacubitril/valsartan hemi-pentahydrate
Tabrez Rafique Shaikh, Christy P. George, Priyanka Bhukya, Nikita Shelke, Komal Ishwar Pawar, Abhijit Garai, Rambabu Dandela, Rajesh G. Gonnade, Ashwini Nangia
Abstract
The synthesis of Entresto, a multidrug cocrystal from sacubitril sodium and valsartan disodium using different conditions yielded six novel crystal forms. Stability studies showed higher stability of Form-I and III over the other crystal forms.
Topics & Concepts
CocrystalValsartanChemistrySupramolecular chemistryCombinatorial chemistryCrystal structureInorganic chemistryCrystallographyMaterials scienceOrganic chemistryHydrogen bondMedicineMoleculeInternal medicineBlood pressureCrystallization and Solubility StudiesCrystallography and molecular interactionsChemical Thermodynamics and Molecular Structure