Safety and pharmacokinetics of islatravir subdermal implant for HIV-1 pre-exposure prophylaxis: a randomized, placebo-controlled phase 1 trial
Randolph P. Matthews, Munjal Patel, Stephanie E. Barrett, Liesbeth Haspeslagh, Tom Reynders, Saijuan Zhang, Sylvie Rottey, Adrian P. Goodey, Ryan Vargo, Jay A. Grobler, S. Aubrey Stoch, Marian Iwamoto
Topics & Concepts
PharmacokineticsPlaceboMedicineTolerabilityPeripheral blood mononuclear cellAdverse effectReverse-transcriptase inhibitorPharmacologyImplantInternal medicineGastroenterologySurgeryHuman immunodeficiency virus (HIV)ImmunologyViral loadChemistryAntiretroviral therapyPathologyIn vitroBiochemistryAlternative medicineHIV/AIDS drug development and treatmentHIV Research and TreatmentHIV/AIDS Research and Interventions