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Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomes

Aditya K. Padhi, Timir Tripathi

2022Biochemical and Biophysical Research Communications44 citationsDOIOpen Access PDF

Topics & Concepts

ProteaseBiologySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Coronavirus disease 2019 (COVID-19)VirologyMutantComputational biologyGeneticsDrug resistanceGeneInfectious disease (medical specialty)MedicineEnzymeBiochemistryDiseasePathologySARS-CoV-2 and COVID-19 Researchvaccines and immunoinformatics approachesBacteriophages and microbial interactions
Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomes | Litcius