Formation of the glomerular microvasculature is regulated by VEGFR-3
Michael D. Donnan, Dilip K. Deb, Tuncer Onay, Rizaldy P. Scott, Eric Ni, Yalu Zhou, Susan E. Quaggin
Abstract
Targeting VEGFR-3 in kidney lymphatics has been proposed as a method to treat kidney disease. However, expression of VEGFR-3 is not lymphatic-specific. We demonstrated developmental expression of VEGFR-3 in glomerular endothelial cells, with loss of Vegfr-3 leading to malformation of glomerular capillary loops. Furthermore, we showed that VEGFR-3 attenuates VEGFR-2 activity in glomerular endothelial cells independent of paracrine VEGF-C signaling. Together, these data provide valuable information for therapeutic development targeting these pathways.
Topics & Concepts
Paracrine signallingLymphatic systemVEGF receptorsLymphatic EndotheliumKidneyCell biologyCancer researchBiologyPathologyMedicineReceptorEndocrinologyInternal medicineLymphatic System and DiseasesRenal and related cancersVascular Malformations and Hemangiomas