Impact of the Dimethyl Sulfoxide Reductase Superfamily on the Evolution of Biogeochemical Cycles
Michael Wells, Minjae Kim, Denise M. Akob, Partha Basu, John F. Stolz
Abstract
The MopB superfamily constitutes a repertoire of metalloenzymes that are central to enduring mysteries in microbiology, from the origin of life and how microorganisms and biogeochemical cycles have coevolved over deep time to how anaerobic life adapted to increasing concentrations of O 2 during the transition from an anoxic to an oxic world. Our work emphasizes that phylogenetic analyses can reveal how domain gain or loss events, the acquisition of novel partner subunits, and the loss of metal cofactors can stimulate novel radiations of enzymes that dramatically increase the catalytic versatility of superfamilies.
Topics & Concepts
Biogeochemical cycleDimethyl sulfoxideSUPERFAMILYEvolutionary biologyChemistryBiologyComputational biologyBiochemistryEnvironmental chemistryGeneOrganic chemistryHydrocarbon exploration and reservoir analysisAtmospheric and Environmental Gas DynamicsMicrobial bioremediation and biosurfactants