Response to Comment on “Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals”
Anneline Pinson, Tomislav Maričić, Hugo Zeberg, Svante Pääbo, Wieland Β. Huttner
Abstract
Herai et al . discuss the known fact that a low percentage of modern humans who lack any overt phenotypes carry the ancestral TKTL1 allele. Our paper demonstrates that the amino acid substitution in TKTL1 increases neural progenitor cells and neurogenesis in the developing brain. It is another question if, and to what extent, this has consequences for the adult brain.
Topics & Concepts
NeurogenesisNeocortexBiologyProgenitor cellNeurosciencePhenotypeProgenitorAlleleHuman brainGeneticsStem cellGeneGenomics and Chromatin DynamicsGenetic Syndromes and ImprintingEpigenetics and DNA Methylation