The rice bran peptide KF-8 extends the lifespan and improves the healthspan of <i>Caenorhabditis elegans via</i> skn-1 and daf-16
Jie Cai, Zhongxu Chen, Yixin Wu, Yajuan Chen, Jianqiang Wang, Qinlu Lin, Ying Liang
Abstract
. We found that KF-8 prolonged the life of nematodes and showed no reproductive toxicity towards nematodes. In addition, KF-8 improved the motility of nematodes and resulted in an extended body length. Using hydrogen peroxide and juglone as stress inducers, we found that KF-8 improved the anti-stress ability of nematodes. In addition, KF-8 upregulated the expressions of skn-1, daf-16 and antioxidant genes. In addition, the life-prolonging effect of KF-8 was lost in skn-1 mutant strains and daf-16 mutant strains, indicating that KF-8 may exert anti-aging effects through skn-1 and daf-16.
Topics & Concepts
Caenorhabditis elegansMutantAntioxidantBiologyJugloneMotilityHydrogen peroxidePopulationPeptideDownregulation and upregulationCell biologyBiochemistryGeneMedicineEnvironmental healthGenetics, Aging, and Longevity in Model OrganismsProtein Hydrolysis and Bioactive PeptidesGDF15 and Related Biomarkers