The RNA-Binding Protein ProQ Promotes Antibiotic Persistence in Salmonella
Alisa Rizvanovic, Charlotte Michaux, Margherita Panza, Zeynep Iloglu, Sophie Hélaine, E. Gerhart H. Wagner, Erik Holmqvist
Abstract
gene outcompete wild-type bacteria under laboratory conditions, are less prone to enter growth dormancy, and form fewer persister cells. The basis for these phenotypes lies in ProQ's ability to activate energy-consuming cellular processes, including flagellar motility and protein secretion. Importantly, we show that ProQ contributes to the persister phenotype during Salmonella infection of macrophages, indicating an important role of this global regulator in Salmonella pathogenesis.
Topics & Concepts
Salmonella entericaMultidrug toleranceBiologyMicrobiologySalmonellaBacteriaBiofilmAntibioticsPhenotypeGeneRNAGeneticsSalmonella and Campylobacter epidemiologyViral gastroenteritis research and epidemiologyBacterial Genetics and Biotechnology