Neuronal miR-138 Represses HSV-2 Lytic Infection by Regulating Viral and Host Genes with Mechanistic Differences from HSV-1
Siyu Chen, Yue Deng, Hongjia Chen, Yuqi Lin, Xuewei Yang, Boqiang Sun, Dongli Pan
Abstract
HSV-1 and HSV-2 are closely related viruses with major differences. Both viruses establish latency in neurons from which they reactivate to cause disease.
Topics & Concepts
BiologyLytic cycleHerpes simplex virusViral replicationVirus latencyVirologyMolecular biologyTransfectionNeurotropic virusVirusHost factorGeneGeneticsHerpesvirus Infections and TreatmentsViral Infections and Immunology ResearchRNA regulation and disease