STARD1 and NPC1 expression as pathological markers associated with astrogliosis in post-mortem brains from patients with Alzheimer's disease and Down syndrome
Fabián Arenas, Fernanda Castro, Susana Núñez, Gemma Gay, Carmen García‐Ruiz, José C. Fernández‐Checa
Abstract
. Hippocampal areas stained with the recombinant GST-PFO probe showed increased mitochondrial cholesterol within astrocytes of brains from patients with AD and DS-brains compared to controls. Lysosomal cholesterol accumulation within hippocampal astrocytes was higher in DS than in AD. These data revealed increased intracellular cholesterol loading in hippocampus from patient with AD and DS and suggest that STARD1 could be a potential pre-clinical marker associated with early stages of AD pathology.
Topics & Concepts
HippocampusAstrogliosisNPC1Hippocampal formationCholesterolAlzheimer's diseaseNeurodegenerationBiologyInternal medicineNiemann–Pick diseasePathologicalEndocrinologyPathologyMedicineDiseaseCentral nervous systemReceptorEndosomeAlzheimer's disease research and treatmentsCellular transport and secretionMitochondrial Function and Pathology