Restoring Prohealing/Remodeling-Associated M2a/c Macrophages Using ON101 Accelerates Diabetic Wound Healing
Ching‐Wen Lin, Chih‐Chiang Chen, Wen‐Yen Huang, Yen‐Yu Chen, Shiou-Ting Chen, Hung‐Wen Chou, Chien‐Min Hung, W.H. Chen, Chia-Sing Lu, Shi-Xin Nian, Shyi-Gen Chen, Hsuen-Wen Chang, Vincent H.S. Chang, Liying Liu, Ming-Liang Kuo, Shun‐Cheng Chang
Abstract
M2 macrophages. Depletion of cutaneous M2 macrophages inhibited ON101-induced diabetic wound healing. Thus, ON101 directly suppressed M1 macrophages and facilitated the GCSF- and CXCL3-mediated transition from M1 to M2 macrophages, lowering inflammation and leading to faster diabetic wound healing.
Topics & Concepts
CD163Proinflammatory cytokineInflammationMacrophage polarizationWound healingM2 MacrophageMacrophageCell biologyProgenitor cellCancer researchChemistryMedicineImmunologyBiologyIn vitroStem cellBiochemistryWound Healing and TreatmentsPressure Ulcer Prevention and ManagementDiabetic Foot Ulcer Assessment and Management