Design and Synthesis of New pyrazole Hybrids Linked to Oxime and Nitrate Moieties as COX-2, EGFRL858R/T790M Inhibitors and Nitric Oxide Donors with dual Anti-inflammatory/Anti-proliferative Activities
Wael A. A. Fadaly, Mohamed T. M. Nemr, Abeer M. Abd El-Hameed, Fatma El Zahraa Ammar Mohamed, Taha H. Zidan
Topics & Concepts
ChemistryPyrazoleNitric oxideOximeHybridNitrateCombinatorial chemistryPharmacologyBiochemistryStereochemistryOrganic chemistryBotanyBiologyMedicineSynthesis and biological activitySynthesis and Biological EvaluationInflammatory mediators and NSAID effects