ALYREF-mediated RNA 5-Methylcytosine modification Promotes Hepatocellular Carcinoma Progression Via Stabilizing EGFR mRNA and pSTAT3 activation
Jiayida Nulali, Kaiwen Zhang, Manmei Long, Yueyue Wan, Yu Liu, Qianyue Zhang, Liu Yang, Jun Hao, Linhua Yang, Huai‐Dong Song
Abstract
. Mechanistically, ALYREF promoted the progression of human LIHC through EGFR pathways. Furthermore, ALYREF could directly bind to the m5C modification site of EGFR 3' untranslated region (3' UTR) to stabilize EGFR mRNA. Collectively, ALYREF played a crucial oncogenic role in LIHC via the stabilization of EGFR mRNA and subsequent activation of the STAT3 signaling pathway. Our results may help to elucidate the potential mechanisms of ALYREF-induced m5C modification in the progression of human LIHC.
Topics & Concepts
BiologyCancer researchMessenger RNAHepatocellular carcinomaTumor progressionUntranslated regionCarcinogenesisCancerGeneGeneticsRNA modifications and cancerCancer-related molecular mechanisms researchRNA Research and Splicing