The LysR-Type Transcriptional Regulator BsrA (PA2121) Controls Vital Metabolic Pathways in <i>Pseudomonas aeruginosa</i>
Magdalena Modrzejewska, Adam Kawałek, Aneta Agnieszka Bartosik
Abstract
gene is increased in the presence of antibiotics, which suggests its induction in response to stress, possibly reflecting the need to redirect metabolism under stressful conditions. This is particularly relevant for the treatment of infections caused by P. aeruginosa. In summary, the findings of this study demonstrate that the BsrA regulator performs important roles in carbon metabolism, biofilm formation, and antibiotic resistance in P. aeruginosa.
Topics & Concepts
RegulonBiologyTranscriptional regulationOperonPseudomonas aeruginosaGeneticsGeneRegulatorRepressorRegulation of gene expressionTranscription factorEscherichia coliBacteriaBacterial biofilms and quorum sensingBacterial Genetics and BiotechnologyAntibiotic Resistance in Bacteria