Dysregulation of Exosome Cargo by Mutant Tau Expressed in Human-induced Pluripotent Stem Cell (iPSC) Neurons Revealed by Proteomics Analyses
Sonia Podvin, Alexander C. Jones, Qing Liu, Brent Aulston, Linnea Ransom, Janneca Ames, Gloria Shen, Christopher B. Lietz, Zhenze Jiang, Anthony J. O’Donoghue, Charisse N. Winston, Tsuneya Ikezu, Robert A. Rissman, Shauna H. Yuan, Vivian Hook
Abstract
propagation of p-Tau neuropathology in mouse brain.
Topics & Concepts
Induced pluripotent stem cellExosomeProteomicsCell biologyMutantBiologyStem cellHuman Induced Pluripotent Stem CellsMicrovesiclesGeneGeneticsEmbryonic stem cellmicroRNAExtracellular vesicles in diseaseRNA Interference and Gene DeliveryRNA Research and Splicing