Successful Detection of Unrecognized <i>Rickettsia typhi</i> in Pregnancy Using Cell‐Free Next‐Generation Sequencing
Irene Stafford, Fernando H Centeno, Mayar Al Mohajer, George R. Parkerson, Laila Woc-Colburn, Angelica Janice Burgos-Lee, Martha Rac, James J. Dunn, Kenneth L. Muldrew
Abstract
. Infection in pregnant women can lead to adverse outcomes when diagnosis and treatment is delayed. We describe how next-generation sequencing (NGS) using the Karius® test was used to rapidly diagnose murine typhus in two pregnant women admitted to a large tertiary care center in Houston, Texas, when all initial testing was nondiagnostic.
Topics & Concepts
Rickettsia typhiMedicineVirologyPregnancyMicrobiologyRickettsiaBiologyGeneticsVirusVector-borne infectious diseasesRabies epidemiology and controlMosquito-borne diseases and control