Glycine Decarboxylase (GLDC) Plays a Crucial Role in Regulating Energy Metabolism, Invasion, Metastasis and Immune Escape for Prostate Cancer
Mingkun Chen, Zhuoyu Xiao, Zhipeng Huang, Kang-Yi Xue, Hui Xia, Jiawei Zhou, De-Ying Liao, Zhi-Jian Liang, Xie Xiao, Qing-Zhu Wei, Lin Zhong, Jian-Kun Yang, Cundong Liu, Yang Liu, Shan‐Chao Zhao
Abstract
. Furthermore, we found that the GLDC-high group had a higher TP53 mutation frequency, lower CD8+ T-cell infiltration, higher immune checkpoint expression, and higher immune exclusion scores than the GLDC-low group. Finally, the GLDC-based prognostic risk model by applying LASSO Cox regression also showed good predictive power for the clinical characteristics and survival in PCa patients. This evidence indicates that GLDC plays crucial roles in glycolytic metabolism, invasion and metastasis, and immune escape in PCa, and it is a potential therapeutic target for prostate cancer.