Water-Tolerant <i>ortho</i>-Acylation of Phenols
Jie‐Sheng Tian, He Yu, Zhiyuan Gao, Xu Liu, Shuang-Feng Dong, Peng Wu, Teck‐Peng Loh
Abstract
A metal-free, water-tolerant, and one-pot process for ortho-acylation of phenols promoted by the iodine source/hydrogen peroxide system has been developed. This transformation undergoes ether formation, iodocyclization, C–C bond cleavage, and oxidative hydrolysis in a one-step manner, which is supported by control experiments.
Topics & Concepts
ChemistryAcylationPhenolsHydrogen peroxideHydrolysisIodineEtherBond cleavageOxidative phosphorylationOxidative cleavageOrganic chemistryCleavage (geology)CatalysisBiochemistryFracture (geology)EngineeringGeotechnical engineeringOxidative Organic Chemistry ReactionsCatalytic C–H Functionalization MethodsChemical Synthesis and Reactions