<i>De novo</i>asymmetric Achmatowicz approach to oligosaccharide natural products
Sugyeom Kim, Jeremy Oiler, Yalan Xing, George A. O’Doherty
Abstract
asymmetric approach centers around the use of asymmetric catalysis for the synthesis of optically pure furan alcohols in conjunction with Achmatowicz oxidative rearrangement for the synthesis of various pyranones. In addition, the use of a diastereoselective palladium-catalyzed glycosylation and subsequent diastereoselective post-glycosylation transformation was used for the synthesis of oligosaccharides. The application of this approach to oligosaccharide synthesis is discussed.
Topics & Concepts
OligosaccharideChemistryEnantioselective synthesisCombinatorial chemistryNatural (archaeology)De novo synthesisStereochemistryOrganic chemistryBiologyCatalysisPaleontologyEnzymeCarbohydrate Chemistry and SynthesisChemical Synthesis and AnalysisGlycosylation and Glycoproteins Research