Type 3 Diabetes and Its Role Implications in Alzheimer’s Disease
Thuy Trang Nguyen, Thuy Trang Nguyen, Qui Thanh Hoai Ta, Thi Kim Oanh Nguyen, Thi Kim Oanh Nguyen, Thi Thuy Dung Nguyen, Thi Thuy Dung Nguyen, Vo Van Giau
Abstract
The exact connection between Alzheimer's disease (AD) and type 2 diabetes is still in debate. However, poorly controlled blood sugar may increase the risk of developing Alzheimer's. This relationship is so strong that some have called Alzheimer's "diabetes of the brain" or "type 3 diabetes (T3D)". Given more recent studies continue to indicate evidence linking T3D with AD, this review aims to demonstrate the relationship between T3D and AD based on the fact that both the processing of amyloid-β (Aβ) precursor protein toxicity and the clearance of Aβ are attributed to impaired insulin signaling, and that insulin resistance mediates the dysregulation of bioenergetics and progress to AD. Furthermore, insulin-related therapeutic strategies are suggested to succeed in the development of therapies for AD by slowing down their progressive nature or even halting their future complications.