Overexpression of small nucleolar RNA SNORD1C is associated with unfavorable outcome in colorectal cancer
Yonghui Liu, Chengwen Zhao, Jing Sun, Guihua Wang, Shaoqing Ju, Cheng Qian, Xudong Wang
Abstract
< 0.05). In the ROC curve analysis, SNORD1C serum expression combined with CEA offered better predictive value for the diagnosis of CRC (AUC = 0.838) compared with SNORD1C (AUC = 0.748) or CEA (AUC = 0.715) alone. High expression of SNORD1C was found to be closely associated with prognosis and unfavorable outcomes in patient with CRC. Therefore, serum SNORD1C may be a noninvasive tumor biomarker for diagnosis of CRC.
Topics & Concepts
KEGGColorectal cancerSmall nucleolar RNACarcinoembryonic antigenReceiver operating characteristicCancerBiomarkerGene ontologyOncologyReal-time polymerase chain reactionMedicineLong non-coding RNAGeneInternal medicineCancer researchBiologyRNAGene expressionGeneticsCancer-related molecular mechanisms researchRNA modifications and cancerCholangiocarcinoma and Gallbladder Cancer Studies