Amplification of oxidative stress with a hyperthermia-enhanced chemodynamic process and MTH1 inhibition for sequential tumor nanocatalytic therapy
Qingcheng Song, Yiran Zhang, Yiran Zhang, Xiangtian Deng, Haiyue Zhao, Yueyao Zhang, Yueyao Zhang, Junyong Li, Wei Chen, Hongzhi Hu, Yingze Zhang, Yingze Zhang
Abstract
We applied dendritic mesoporous silica NPs (DMSN NPs) as the deposition matrices to achieve a high dispersion of CeO 2 NPs. Hyperthermia-enhanced CDT combined with DNA damage repair pathway inhibition has a powerful tumor inhibition efficiency.
Topics & Concepts
Photothermal therapyDNA damageOxidative stressIn vivoCatalysisRedoxDNAChemistryGlutathioneOxidative phosphorylationBiophysicsCombinatorial chemistryBiochemistryCancer researchMaterials scienceNanotechnologyBiologyEnzymeOrganic chemistryBiotechnologyNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisExtracellular vesicles in disease